Manavella Lab
/plant small RNAs biology lab
/papers
"Polymorphic inverted repeats near coding genes impact chromatin topology and phenotypic traits in Arabidopsis thaliana"
Arce AL, Mencia R, Cambiagno DA, Lang PL, Liu C, Burbano HA, Weigel D, Manavella PA.
Cell Reports. 2023; 42(1):112029.
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"The HOS15-HDA9 complex associates with HYL1 to modulate miRNA expression in response to ABA signaling"
Park J, Giudicatti AJ, Bader ZE, Han MK, Møller C, Arce AL, Xu ZY, Yang SW, Manavella PA*, Yun DJ*.
Plant Cell. 2023; koad132.
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"The eINTACT system dissects bacterial exploitation of plant osmosignalling to enhance virulence"
You Y, Koczyk G, Nuc M, Morbitzer R, Holmes DR, von Roepenack-Lahaye E, Hou S, Giudicatti A, Gris C, Manavella PA, Noël LD, Krajewski P, Lahaye T.
Nature Plants. 2023; 9(1):128-141.
"Beyond transcription: compelling open questions in plant RNA biology"
Manavella PA, Godoy Herz MA, Kornblihtt AR, Sorenson R, Sieburth LE,Nakaminami K, Seki M, Ding Y, Sun Q, Kang H, Ariel FD, Crespi M, Giudicatti AJ,Cai Q, Jin H, Feng X, Qi Y, Pikaard CS.
Plant Cell. 2023; 35(6):1626-1653.
"Cotranscriptional RNA processing and modification in plants"
Marquardt S, Petrillo E, Manavella PA.
Plant Cell. 2023; 35(6):1654-1670.
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"A ribose world: current status and future challenges of plant RNA biology"
Marquardt S, Manavella PA.
J Exp Bot. 2023; 74(7):2203-2207.
"Focus on RNA biology"
Eckardt NA, Axtell MJ, Barta A, Chen X, Gregory BD, Guo H, Manavella PA, Mosher RA, Meyers BC.
Plant Cell. 2023; 35(6):1617-1618.
"Keeping up with the miRNAs: current paradigms of the biogenesis pathway"
Mencia R, Gonzalo L, Tossolini I, Manavella PA.
J Exp Bot. 2023; 74(7):2213-2227.
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"R-loops at microRNA encoding loci promote co-transcriptional processing of pri-miRNAs in plants"
Gonzalo, L., Tossolini, I., Gulanicz, T., Cambiagno, D.A., Kasprowicz-Maluski, A., Smolinski, D.J., Mammarella, M.F., Ariel, F.D., Marquardt, S., Szweykowska-Kulinska, Z., Jarmolowski, A., Manavella, P.A.
Nature Plants. 2022; 8(4):402-418
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Arabidopsis AAR2, a conserved splicing factor in eukaryotes, acts in microRNA biogenesis.
Fan L, Gao B, Xu Y, Flynn N, Le B, You C, Li S, Achkar N, Manavella PA, YangZ, Chen X
Proc Natl Acad Sci U S A. 2022; 119(41):e2208415119.
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"Prospects for plant productivity: From the canopy to the nucleus"
González, F.G., Manavella, P.A.
Journal of Experimental Botany. 2021; 72 (11):3931-3935
"When junk DNA turns functional: Transposon-derived non-coding RNAs in plants"
Ariel, F.D., Manavella, P.A.(2021)
Journal of Experimental Botany. 2021; 72(11):4132-4143
"HASTY modulates miRNA biogenesis by linking pri-miRNA transcription and processing"
Cambiagno, D.A., Giudicatti, A.J., Arce, A.L., Gagliardi, D., Li, L., Yuan, W., Lundberg, D.S., Weigel, D., Manavella, P.A.
Molecular Plant. 2021; 14 (3):426-439
Giudicatti, A.J., Tomassi, A.H., Manavella, P.A., Arce, A.L.
"Extensive analysis of miRNA trimming and tailing indicates that AGO1 has a complex role in miRNA turnover"
Plants. 2021; 10(2):1-14
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"The Intrinsically Disordered Protein CARP9 Bridges HYL1 to AGO1 in the Nucleus to Promote MicroRNA Activity"
Tomassi AH, Re DA, Romani F, Cambiagno DA, Gonzalo L, Moreno JE, Arce AL, Manavella PA.
Plant Physiology. 2020; 184(1):316-329
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"Short-range regulatory chromatin loops in plants"
Gagliardi D, Manavella PA.
New Phytologist. 2020; 228(2):466-471
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"The AtHB1 Transcription Factor Controls the miR164-CUC2 Regulatory Node to Modulate Leaf Development"
Miguel VN, Manavella PA, Chan RL, Capella MA.
Plant & Cell Physiology. 2020; 61(3):659-670.
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Choi SW, Ryu MY, Viczián A, Jung HJ, Kim GM, Arce AL, Achkar NP, Manavella P, Dolde U, Wenkel S, Molnár A, Nagy F, Cho SK, Yang SW.
Molecular Plant. 2020; 13(3):431-445.
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"CURLY LEAF Regulates MicroRNA Activity by Controlling ARGONAUTE 1 Degradation in Plants"
Ré DA, Cambiagno DA, Arce AL, Tomassi AH, Giustozzi M, Casati P, Ariel FD, Manavella PA.
Molecular Plant. 2020; 13(1):72-87.
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"Dynamic regulation of chromatin topology and transcription by inverted repeat-derived small RNAs in sunflower"
Gagliardi D, Cambiagno DA, Arce AL, Tomassi AH, Giacomelli JI, Ariel FD, Manavella PA
Proc Natl Acad Sci U S A. 2019; 116(35):17578-17583.
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"Keep calm and carry on: miRNA biogenesis under stress"
Manavella PA, Yang SW, Palatnik JF.
The Plant Journal. 2019; 99(5):832-843
"Alternative use of miRNA-biogenesis co-factors in plants at low temperatures"
Ré DA, Lang PLM, Yones C, Arce AL, Stegmayer G, Milone D, Manavella PA.
Development. 2019; 146(5). pii: dev172932.
"A quick HYL1-dependent reactivation of microRNA production is required for a proper developmental response after extended periods of light deprivation"
Achkar NP, Cho SK, Poulsen C, Arce AL, Re DA, Giudicatti AJ, Karayekov E, Ryu MY, Choi SW, Harholt J, Casal JJ, Yang SW, Manavella PA
Developmental Cell. 2018; 46(2):236-247
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"Class I and class II TCP transcription factors modulate SOC1-dependent flowering at multiple levels"
Lucero LE, Manavella PA, Gras DE, Ariel FD, Gonzalez DH
Molecular Plant. 2017; 10(12):1571-1574
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"Nonradioactive detection of small RNAs using digoxigenin-labeled probes"
Tomassi AH, Gagliardi D, Cambiagno DA, Manavella PA
Methods in Molecular Biology. 2017; 1640:199-210
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"miRNA Biogenesis: A Dynamic Pathway"
Achkar NP, Cambiagno DA and Manavella PA.
Trends in Plant Science 2016; 21(12):1034-1044.
"KH domain protein RCF3 is a tissue-biased regulator of the plant miRNA biogenesis cofactor HYL1"
Karlsson P, Christie MD, Seymour DK, Wang H, Wang X, Hagmann J, Kulcheski F and Manavella PA
Proc Natl Acad Sci U S A. 2015; 112(45):14096-14101.
"Caught in a TrAP"
Ré DA and Manavella PA
eLife. 2015; 4:e11509
“THO2, core member of the THO/TREX complex, is required for micro RNA production in Arabidopsis”
Francisco A, Karlsson P, Kim MH, Eo HJ, Oh SA, Kim JH, Kulcheski F, Park SK, Manavella, PA
Plant Journal. 2015; 82(6):1018-1029
"Germline-Transmitted Genome Editing in Arabidopsis thaliana Using TAL-Effector-Nucleases"
Forner J, Pfeiffer A, Langenecker T, Manavella PA and Lohmann JU
PLoS One. 2015; 10(3):e0121056
“DNA Topoisomerase 1α Promotes Transcriptional Silencing of Transposable Elements through DNA Methylation and Histone Lysine 9 Dimethylation in Arabidopsis”
Dinh TT, Gao L, Liu X, Li D, Li S, Zhao Y, O’Leary M, Le B, Schmitz RJ, Manavella PA, Li S, Weigel D, Pontes O, Ecker JR, and Chen X
PLoS Genetics. 2014; 10(7):e1004446.
“Tissue-specific silencing of Arabidopsis SU(VAR)3-9 HOMOLOG8 by miR171a.”
Manavella PA, Koenig D, Rubio-Somoza I, Burbano HA, Becker C, Weigel D.
Plant Physiol. 2013; 161(2):805.
“Fast-forward genetics identifies plant CPL phosphatases as regulators of miRNA processing factor HYL1.”
Manavella PA, Hagmann J, Ott F, Laubinger S, Franz M, Macek B, Weigel D.
Cell. 2012;151(4):859.
“Role of recently evolved miRNA regulation of sunflower HaWRKY6 in response to temperature damage.”
Giacomelli JI, Weigel D, Chan RL, Manavella PA.
New Phytol. 2012; 195(4):766.
“Plant secondary siRNA production determined by microRNA-duplex structure.”
Manavella PA, Koenig D, Weigel D.
Proc Natl Acad Sci U S A. 2012; 109(7):2461.
“Argonaute10 as a miRNA locker.”
Manavella PA, Weigel D, Wu L.
Cell. 2011; 145(2):173.
“Mimicry technology: suppressing small RNA activity in plants.”
Rubio-Somoza I, Manavella PA.
Methods Mol Biol. 2011; 732:131.
“Engineering elements for gene silencing: the artificial microRNAs technology.”
Manavella PA, Rubio-Somoza I.
Methods Mol Biol. 2011; 732:121.
“HAHB10, a sunflower HD-Zip II transcription factor, participates in the induction of flowering and in the control of phytohormone-mediated responses to biotic stress.”
Dezar CA, Giacomelli JI, Manavella PA, Ré DA, Alves-Ferreira M, Baldwin IT, Bonaventure G, Chan RL.
J Exp Bot. 2011; 62(3):1061.
“Transient transformation of sunflower leaf discs via an Agrobacterium-mediated method: applications for gene expression and silencing studies.”
Manavella PA, Chan RL.
Nat Protoc. 2009; 4(11):1699.
“HAHB4, a sunflower HD-Zip protein, integrates signals from the jasmonic acid and ethylene pathways during wounding and biotic stress responses.”
Manavella PA, Dezar CA, Bonaventure G, Baldwin IT, Chan RL.
Plant J. 2008; 56(3):376-88.
“The sunflower HD-Zip transcription factor HAHB4 is up-regulated in darkness, reducing the transcription of photosynthesis-related genes.”
Manavella PA, Dezar CA, Ariel FD, Drincovich MF, Chan RL.
J Exp Bot. 2008; 59(11):3143.
“Two ABREs, two redundant root-specific and one W-box cis-acting elements are functional in the sunflower HAHB4 promoter.”
Manavella PA, Dezar CA, Ariel FD, Chan RL.
Plant Physiol Biochem. 2008; 46(10):860.
“The true story of the HD-Zip family.”
Ariel FD, Manavella PA, Dezar CA, Chan RL.
Trends Plant Sci. 2007; 12(9):419.
“The ZFHX1A gene is differentially autoregulated by its isoforms.”
Manavella PA, Roqueiro G, Darling DS, Cabanillas AM.
Biochem Biophys Res Commun. 2007; 360(3):621.
“The intron of the Arabidopsis thaliana COX5c gene is able to improve the drought tolerance conferred by the sunflower Hahb-4 transcription factor.”
Cabello JV, Dezar CA, Manavella PA, Chan RL.
Planta. 2007; 226(5):1143-54.
“Cross-talk between ethylene and drought signalling pathways is mediated by the sunflower Hahb-4 transcription factor.”
Manavella PA, Arce AL, Dezar CA, Bitton F, Renou JP, Crespi M, Chan RL.
Plant J. 2006; 48(1):125-37.
